What Are The Main Side Effects of Vitiligo Treatments?

What are the main side effects of vitiligo  treatments? 

Key points 

Topical and systemic treatments of vitiligo may have different side effects in different subjects. 

Topical potent corticosteroids are considered to be first-line therapy. Erythema, acne-form lesions, atrophy of  the epidermis, teleangectasia, striae distensae and increased hair growth are commonly reported. 

Topical calcineurine inhibitors (Tacrolimus, Pimecrolimus) commonly induce erythema, burning, and irritation.  In spite of some circulating information, to date there is no convincing evidence suggesting that there is any  increase in skin cancer after their use in vitiligo subjects. 

Vitamin D3 analogs may only produce mild irritation on the treated skin. 

Topical psoralens are highly phototoxic even in very low concentrations after UV exposure: blistering and skin  necrosis may be seen. 

Answer 

Treatment of vitiligo is a complex issue which  always requires a clear and exhaustive  explanation of side effects of both systemic and  local treatments. Each vitiligo patient should ask the  dermatologist about the length of the treatment(s)  as well as possible side effects. 

The discussion of any systemic treatments of  vitiligo requires always a discussion in private  between the vitiligo patient and her/his  dermatologist in a most empathic and cooperative  setting based on clear questions and clear  answers. Hopefully, this mini-book will help the  patient(s) in rising clear answers to the  dermatologist to achieve better understanding and  treating vitiligo.